ABSTRACT
The aim of this study was to compare serum telomerase, CBC and insulin resistance and their relationship with physical fitness factors in active and sedentary elderly people under quarantine of coronavirus. In this study, healthy men and women with a mean age of 61.43+/-6/07 in coronavirus pandemic conditions participated in this study voluntarily. Subjects were divided into three groups of physical activity: high, medium and low. The international Physical Activity Level Questionnaire (IPAQ) was used to assess the level of physical activity. Serum telomerase, CBC and insulin resistance were measured in different groups after measuring physical fitness factors. Results showed that BMI is higher in the sedentary group than the groups with moderate and high levels of physical activity;In addition, blood Hb and Hct levels were higher in the moderate physical activity group than in the sedentary group, but blood Plt levels were lower in the moderate physical activity group than in the sedentary group. Another result of the present study was the negative correlation of telomerase with BMI and the positive correlation of telomerase with Hb, Hct and RBC, although there was no correlation between telomerase and physical fitness factors. In addition, BMI was negatively correlated with fitness factors, glucose levels, insulin resistance and CBC. Physical fitness in the elderly people under quarantine of coronavirus has a positive relationship with some blood parameters but no correlation was observed between telomerase and insulin resistance with physical fitness.Copyright © 2022, Venezuelan Society of Pharmacology and Clinical and Therapeutic Pharmacology. All rights reserved.
ABSTRACT
COVID-19, which is caused by the SARS-Cov-2, begins with early symptoms of fever, cough, shortness of breath, myalgia, and fatigue, affecting the lungs with pneumonia and causing acute respiratory distress syndrome (ARDS). Also, the onset of the disease may with rapid progression, lead to organ dysfunction, such as acute kidney or liver damage, and even death in severe cases. Many scientific efforts are underway around the world to identify the appropriate treatment for this disease. Curcumin is a natural polyphenolic compound, which could be a potential treatment option for patients with Covid-19. In this study, we review some of the possible effects of curcumin, such as inhibiting virus entry into the cell, inhibiting virus replication and viral protease, as well as modulating some intracellular messenger pathways. To comprehensive literature review, information from an internet search of English language databases PubMed, Scopus, Web of Science and ScienceDirect as well as Persian language databases such as SID using related keywords based on MESH such as COVID-19, SARS-COV-2, Curcumin and curcuminoid between January 2020 and January 2021 were collected. This review provides some possible effects of curcumin and its mechanisms for the treatment of COVID-19.